IgA Antibodies Carrying the b12 V Region and Cell Transfer by Human Monoclonal IgG Inhibition of HIV-1 Infectivity and Epithelial
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Inhibition of IL-13 by Antisense Oligonucleotide Changes Immunoglobulin Isotype Profile in Cultured B-Lymphocytes
The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in the IgE and other immunoglobulin development. Antisense oligo for human IL-13 m-RNA was used to study IgE down regulation. Human B-lymphocytes were purified by positive selecti...
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Mucosal surfaces are the main natural site of entry into the body for human immunodeficiency virus (HIV). Herein, an alternative mechanism for virus spread is described. The mechanism, which involves transcytosis of endosome-internalized HIV-particles, was generated by contact of HIV-infected cells with the apical surface of an epithelial cell line. Transcytosed viruses rapidly (in 20-30 min) a...
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Background: Immunoglobulins are a group of proteins have important role in defense against microorganisms. Human immunoglobulins are divided into five classes: IgA, IgM, IgD, IgE and IgG. Immunoglobulin G (IgG) is the highest abundant antibody in serum and extravascular fluids. The extent of serum IgG is related to severity of several diseases such as infections, so IgG has great diagnostic wor...
متن کاملA significant proportion of the protection mediated by the immune system against reinfection with influenza virus is due to the presence of neutralizing antibody directed against the hemagglutinin
A significant proportion of the protection mediated by the immune system against reinfection with influenza virus is due to the presence of neutralizing antibody directed against the hemagglutinin (HA) 1 of influenza virus (1-5). However, little is understood about the mechanism by which interaction of neutralizing antibody with virus results in loss of infectivity. The consensus of opinion has...
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تاریخ انتشار 2007